Health

Introduction To Fas Ligand (FasL) & Meso Scale Discovery (MSD)

Meso Scale Discovery Assays (MSD ECL) are superior to traditional ELISA in many aspects, even as the various viable assay versions are quite like different types of ELISA. MSD Quick Plex 120 instrument applies the robust and sensitive electrochemiluminescence technology to quantitate single and multiple target analytes in a broad range of sample types such as blood, serum, and tissue. MSD Assays enable accurate determination of analytes in complex biological matrices with improved throughput in a cost-effective manner. MSD QuickPlex 120 instruments apply the robust and sensitive electrochemiluminescence technology to quantitate single and multiple target analyte, including many clinically proven biomarkers. MSD Assays enable accurate determination of analytes in complex biological matrices with improved throughput in a cost-effective and timely manner. Specifically, we can use MSD to analyze many clinically proven biomarkers such as CK, creatinine, TP, GC levels and more., perform PK/TK analysis, etc.

The MSD ECL Assay is a bioanalytical platform that utilizes electrochemiluminescence, unlike the colorimetric or chemiluminescent reaction in ELISA, as a signal detection technique. Mesoscale discovery ECL Assays are superior to traditional ELISA (e.g., semi-spektrometry, enzyme immunosorbent assay, enzyme-labeled test strips) in many aspects and can be utilized for quantitation of single target molecules as well as for detection of multiple targets in complex biological matrices with improved throughput in a cost-effective manner. The MSD Meso Scale Discovery Assay System is a robust and sensitive electrochemiluminescence technology that enables accurate quantitation of a single or multiple analyte in complex biological matrices. The assay system uses highly sensitive electrochemiluminescence technology to detect analytes in complex biological matrices with improved throughput in a cost-effective and timely manner.

Fas ligand or FasL (CD178 or CD95L) is a homotrimeric human type II transmembrane protein. This molecule is encoded by the FASLG gene on chromosome 1q24.3, which encodes the Fas ligand protein. Cytotoxic T lymphocytes express FasL on their surfaces that belong to the TNF family of proteins. By binding to its receptors, FasL induces apoptosis in cells. Studies have discovered around eight splice variants that translate into seven protein isoforms, and they associate many of these isoforms with disease states. FasL is a trimeric death receptor. Fas ligand or FasL (CD178 or CD95L) is a homotrimeric human type II transmembrane protein. The Fas ligand gene (FASLG) on chromosome 1q24.3 encodes the Fas ligand protein. Cytotoxic T lymphocytes express FasL on their surfaces that belong to the TNF family of proteins. By binding to its receptors, FasL induces apoptosis in cells. A matrix metalloproteinase MMP-7 cleaves membrane bound FasL and generates a soluble FasL.

FasL or FasL (CD178 or CD95L) is a homotrimeric human type II transmembrane protein with 8 membrane-spanning domains. The Fas ligand gene encodes a hormone that acts on the surface of immune cells to induce apoptosis in target cells. The Fas receptor is present on the surface of the target cell. Post FasL/FasR binding, the trimerizes and signals the cell for apoptosis. Studies have discovered around eight splice variants that translate into seven protein isoforms, and they associate many of these isoforms with disease states.

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